| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 1
| Issue : 2 | Page : 88-95 |
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The Role of the Immune System in the Pathophysiology of Essential Hypertension
Mahsa Rekabi1, Zahra Daneshmandi1, Elham Sadati1, Mahsa Mirzendehdel1, Seyed Alireza Mahdaviani1, Ali Valinejadi2, Ali Akbar Velayati1, Parisa Honarpisheh1
1 Department of Pediatric, Pediatric Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
Correspondence Address:
Dr. Parisa Honarpisheh
Department of Pediatric, Pediatric Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital, Tehran
Iran
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/jpdtsm.jpdtsm_19_22
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Hypertension (HTN) is a critical worldwide health issue and an imperative risk factor for the development of cardiovascular disease and kidney disease. There are many crevices in our knowledge about the pathophysiology of HTN. The mechanisms intervening in HTN are complex. In recent years, a large scale of evidence supports the role of various components of the innate and adaptive immune systems (such as immune cells subsets, cytokines, complement system, and toll-like receptors) as contributors to HTN and developed end-organ damage. The endpoint of all these pathways is to develop an inflammatory condition that leads to HTN and damage to the end organ. Despite the availability of different antihypertensive drugs, there are still many patients with persistent or uncontrolled HTN. Therefore, understanding these immune pathways and their effects on patients with resistant hypertension. In addition, finding the detailed immunopathogenesis may help us find more targeted therapeutic approaches and improve cardiovascular and renal function in this high-risk untreated population. This review article summarizes different conducted studies on immunity and HTN that indicate the basic role of the immune system in causing HTN.
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