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Year : 2022  |  Volume : 1  |  Issue : 2  |  Page : 134-137

Pharmacological interrelationship analysis between Lentinula Edodes and COVID-19: A pathway analysis

Sant Tukaram Nagar, Pimpri Colony, Pimpri-Chinchwad, Maharashtra, India

Correspondence Address:
Dr. Rujittika Mungmunpuntipantip
Dr DY Patil University, Pune, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpdtsm.jpdtsm_20_22

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BACKGROUND: Learning about the numerous ways traditional plants can be used to address medical concerns is fascinating. Many researches are being conducted to investigate the effects of traditional herbal mushrooms in the treatment of a variety of medical ailments, including respiratory disorders. MATERIALS AND METHODS: In this study, we used network pharmacology to identify a biological relationship between the pharmacological influence of shiitake or Lentinula edodes, a traditional Asian medicinal fungus, and coronavirus disease-2019 (COVID-19) pathophysiology. RESULTS: Using interrelationship analysis, the scientists revealed the common pathway through inducing mitochondrial membrane potential loss. CONCLUSION: The use of L. edodes to treat COVID-19 could be useful. It is suggested that more research be done on the efficacy of shiitake mushrooms in the treatment of COVID-19. Based on the findings of this study, a method to combat COVID-19 using a locally available herbal regimen should be a current high priority research field. The primary in silico study's likely alternate option should be advanced to in vitro and in vivo research as a result.

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